Neurological and Genetic disorders

Cerebral Palsy is a group of permanent movement disorders that appear in early childhood and is caused by abnormal development or damage to the parts of the brain that control movement, balance and posture. Periventricular leukomalacia (PVL) characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles (is a form of white-matter brain injury). White matter damage can cause severe problems with motor coordination or organ function. Most frequent signs include delayed motor development, vision deficits, apneas, low heart rates, and seizures. Abnormal Brain Development begins long before the baby is born. It damages the developing nervous system or causes it to develop abnormally. Sometimes it's a genetic reason, or may be because of exposure to certain medicines, infections, or radiation during pregnancy that interferes with brain development. Intracranial Haemorrhage refers to any bleeding within the intracranial vault, including the brain parenchyma and surrounding meningeal spaces. Bilirubin encephalopathy is a rare neurological condition that occurs in some new-borns because of very high levels of bilirubin. If the level of bilirubin is very high, this can lead to brain damage and hearing loss. Acute intermittent porphyria is a genetic metabolic disorder affecting the production of haem, the oxygen-binding prosthetic group of haemoglobin. ADULT syndrome (Acro–dermato–ungual–lacrimal–tooth) is a rare genetic disease .It is an autosomal dominant form of ectodermal dysplasia, a group of disorders that affects the hair, teeth, nails, sweat glands. The syndrome arises from a mutation in the TP63 gene .Other disorders include: Aicardi–Goutières syndrome, Alexander disease, Alternating hemiplegia of childhood, Birt–Hogg–Dubé syndrome, Brunner syndrome, Aarskog–Scott syndrome, ABCD syndrome, Sickle-cell disease, Spinal muscular atrophy, Color blindness, Haemochromatosis, Autism, Alexander disease, Batten disease, Childhood disintegrative disorder, Leigh syndrome, Lysosomal storage disease, Neonatal encephalopathy etc.

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