Recent advances in Pediatric Gastroenterology and Hepatology

Gut microbiome in specific, has become the main research interest in clinical, medical and microbiology fields to know up to which extent the gut microbiota sustain health and how its disruption might contribute to disease pathogenesis. A major role for the gut microbiota in liver disorders is also supported by the accumulating evidence that several complications of severe liver disease such as hepatic encephalopathy are efficiently treated by various prebiotics, probiotics and antibiotics. Genetics and genomics are beginning to strongly influence the care of patients from common disorders such as colorectal cancer, pancreatitis and liver cancer; to rare conditions like hereditary disorders. Hepatic stellate cells are pericytes found in the perisinusoidal space of the liver, whose main functions is to store vitamin A and probably to maintain the normal basement membrane-type matrix. Gastroesophageal reflux disease is a long-term condition where stomach contents come back up into the esophagus resulting in complications. Symptoms include: burning sensation in your chest, heartburn, vomiting etc. Peptic ulcers are open sores that develop on the inside lining of your stomach and the upper portion of your small intestine. Peptic ulcers include gastric ulcers, duodenal ulcers. Fatty liver is a reversible condition wherein large vacuoles of triglyceride fat accumulate in liver cells via the process of steatosis .Other diseases include: Inflammatory Bowel disease (Crohn’s Disease and Ulcerative Colitis) , Inguinal hernia in children , Hypertrophic Pyloric Stenosis ,  Constipation, Hirschsprung’s Disease ,  Lactose intolerance etc.

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